Preimplantation Genetic Testing (PGT)

Ensuring Healthy Embryos for a Successful Pregnancy

Preimplantation Genetic Testing (PGT) is a cutting-edge fertility technology that allows for the screening of embryos before implantation in an IVF cycle. This genetic testing can help detect chromosomal abnormalities, genetic disorders, or structural rearrangements that may impact embryo viability, increasing the likelihood of a healthy pregnancy.

Why is Preimplantation Genetic Testing Important?

The leading cause of failed IVF cycles is the failure of an embryo to implant or early miscarriage, often due to chromosomal abnormalities. PGT enables us to select the healthiest embryos for transfer, improving pregnancy success rates while reducing the risk of genetic conditions.

Types of Preimplantation Genetic Testing

1. PGT-A (Aneuploidy Screening)

PGT-A, or Preimplantation Genetic Testing for Aneuploidy, assesses the number of chromosomes in each embryo.
✔ Normal embryos should contain 46 chromosomes (euploid).
✔ Abnormal embryos (aneuploid) may have an extra or missing chromosome, reducing implantation potential and increasing miscarriage risk.

PGT-A can detect conditions such as:

• Trisomy 21 (Down Syndrome)
• Turner Syndrome (X0)
• Other chromosomal imbalances that cause implantation failure or miscarriage.

Who Can Benefit from PGT-A?

• Women over 35, as age increases the risk of chromosomal abnormalities.
• Couples with a history of recurrent miscarriages.
• Couples with multiple failed IVF cycles.
• Men with poor sperm quality, increasing the likelihood of embryo abnormalities.

PGT-A improves the chances of a successful pregnancy by ensuring only chromosomally normal embryos are transferred.

2. PGT-M (Testing for Monogenic Diseases)

PGT-M, or Preimplantation Genetic Testing for Monogenic Disorders, is used when one or both partners carry a hereditary genetic condition that could be passed on to the child.

Common conditions screened with PGT-M include:
✅ Cystic Fibrosis
✅ Sickle Cell Disease
✅ Huntington’s Disease
✅ BRCA1 & BRCA2 Mutations (Hereditary Breast Cancer Syndrome)
✅ Duchenne Muscular Dystrophy
✅ Thalassemia (Alpha & Beta)

Who Needs PGT-M?
✔ Couples who are carriers of the same recessive disorder (e.g., Cystic Fibrosis).
✔ Individuals with a dominant genetic mutation (e.g., Huntington’s disease).
✔ Families with a history of genetic disorders.

With PGT-M, we ensure that only embryos free from the inherited disease are selected for implantation, preventing the transmission of genetic conditions.

3. PGT-SR (Testing for Structural Rearrangements)

PGT-SR, or Preimplantation Genetic Testing for Structural Rearrangements, is for couples where one partner carries a chromosomal abnormality (e.g., translocations, deletions, duplications).

📌 These structural rearrangements can lead to:
❌ Repeated miscarriages.
❌ Embryos with missing or extra genetic material.
❌ Increased risk of birth defects or developmental disorders.

PGT-SR ensures that only embryos with the correct genetic balance are transferred, reducing the risk of miscarriage and increasing the chances of a healthy baby.

Is Preimplantation Genetic Testing Right for You?

✔ If you have experienced multiple IVF failures.
✔ If you have had recurrent pregnancy loss.
✔ If you or your partner carry a genetic disorder.
✔ If you are of advanced maternal age (35+).

At Thely Clinic, we provide personalized guidance to help you make informed decisions about preimplantation genetic testing, ensuring the healthiest possible start for your future family.